considered a safer substitute for cigars and pipe tobacco, especially for bystanders;
their weight control benefits could be touted for people who can’t tolerate cigars. Now
imagine that the laboratory bioassay data that accumulated from the 1950s onward,
including the Lovelace studies, were available for hazard evaluation. Would they carry
the day in the current regulatory climate?
Experience suggests no. Claims that “high”—compared to prevailing—exposure levels
in laboratory bioassays are suspect or irrelevant have undermined concerns for health
risks to people at lower levels. For example, the observation that pigment-grade titanium dioxide caused lung cancer in rats was denigrated by the producers because the
exposure level was 250 mg/m3. The “clearance overload” hypothesis was trotted out, as
it was for silica. There was less complaint about the results of bioassays of ultra-fine titanium dioxide (about half of current nanotechnology by weight), which is more potent
and causes increased cancer at lower gravimetric doses. Although IARC classified both
size types as Group 2B carcinogens, possibly carcinogenic to humans, nothing has been
done on the regulatory front.
Franklin Mirer, PhD, CIH, is a professor in the Environmental and Occupational Health Sciences Urban Public
U.S. Department of Health and Human Services, Public Health Service, National
Toxicology Program: “Tobacco Related Exposures,” from Reporton Carcinogens,
Eleventh Edition. Washington, D.C.: 2005. Online at http://ntp.niehs.nih.gov/ntp/
Circle Fax-back Card No. 24
Check out the newest publication to hit the shelves of AIHA
The Radiation Safety Officer Survival Handbook
By Joseph Vincelli, Norman W. Henry III, MS, CIH, John Miller, CHP, James R. Weldy, CHP, CIH
The use of radiation in research, medicine, and industry is highly regulated. Safety professionals working with radiation must possess not only a good understanding of science but
also of regulatory requirements. The RSO Handbook provides an introduction to radiation
safety, including basic radiation science, radiation safety practices and procedures, and
federal or state regulations. References and examples of forms to be used for surveys, audits, or other specific investigations. The information provided in this reference will benefit
the RSO working in an academic, research or medical facility.
AIHA Publications—Reliable References for OEHS Professionals Globally
Check out this book and all others
Call AIHA Customer Service at (703) 849-8888 for more information.